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Low Dose Naltrexone

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Low Dose Naltrexone

Low dose naltrexone may be beneficial for the treatment of various conditions including chronic pain and autoimmune illnesses. Naltrexone is typically used to treat opioid use disorder and alcohol abuse disorder. It is classified as an opioid antagonist blocking the effects of exogenously administered opioids. Naltrexone at low doses (0.5mg - 6mg) has been prescribed for its possible analgesia and anti-inflammatory effects, which have not been observed at higher doses.

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This medication requires a prescription.

To process your order we will require a prescription from you or your Prescriber. We will only compound and dispense upon receipt of a valid patient specific prescription.

  • Your prescriber can mail or fax in the prescription
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  • You can transfer your prescription from another pharmacy
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Pharmacy Info

We are a nationally accredited PCAB compounding pharmacy and a .Pharmacy verified website. A verified .Pharmacy website designation ensures our patients and prescribing partners that our website is verified and safe.

https://safe.pharmacy/buy-safely/?url=cfspharmacy.pharmacy

Drug Description

Actual product image may vary.

Product Info

Naltrexone is typically used to treat opioid use disorder and alcohol abuse disorder. It is classified as an opioid antagonist blocking the effects of exogenously administered opioids. However, at low doses (0.5mg–6mg), oral naltrexone has been prescribed for its possible analgesia and anti-inflammatory effects, which have not been observed at higher doses. Low dose naltrexone may be beneficial for the treatment of various conditions including chronic pain and autoimmune illnesses.

Pronunciation

nal trek sown

Brand Names

Vivitrol, ReVia, APO-Naltrexone

Drug Class

Antidote, Opioid Antagonist

🔬 Mechanism of Action

As a pure opioid antagonist, naltrexone competes with opioid receptors and can displace opioid drugs from the receptors. Naltrexone antagonizes the effects of opioids with long-lasting effects. At low doses, this transient receptor blockade is believed to trigger an upregulation of endogenous opioid production, resulting in anti-inflammatory and analgesic effects.

📊 Administration & Dosing

  • May be taken by mouth with or without food. Taking with food may minimize gastrointestinal side effects.
  • LDN doses typically range from 0.5mg to 6mg daily — contact your healthcare provider for specific dosing instructions.
  • To minimize risk of withdrawal, patients should be opioid-free for at least 7–10 days before starting.

⚠️ Drug Interactions

  • Opioids: Do not take together — may precipitate opioid withdrawal and reduce opioid effectiveness.
  • Bremelanotide: Do not take together — may result in naltrexone treatment failure.
  • Opioid antagonists (Naldemedine, Naloxegol): May increase risk of opioid withdrawal.

🚨 Adverse Effects

Common side effects:

• Nausea / vomiting

• Gastrointestinal pain / cramps

• Joint or muscle pain

• Difficulty sleeping

• Anxiety

• Headaches

Tell your doctor immediately if you experience: yellowing of the skin (jaundice), suicidal thoughts, symptoms of opioid withdrawal, or mild symptoms that do not go away.

🤰 Pregnancy, Breastfeeding & Pediatrics

  • Pregnancy: Testing is recommended prior to initiation. Naltrexone and its metabolite (6-beta-naltrexol) cross the placenta. Limited data exists — speak to your doctor about risks and benefits.
  • Breastfeeding: Naltrexone and 6-beta-naltrexol are present in breast milk. Discuss risk and benefits with your doctor.
  • Pediatrics: Safety and effectiveness have not been established in pediatric patients.

📚 References

  1. Naltrexone [monograph]. In: Lexicomp Online [online database]. Hudson, OH: Lexicomp (accessed 2020 June 11).
  2. Naltrexone [monograph]. In: Micromedex [online database]. Greenwood Village, CO: Truven Health Analytics (accessed 2020 June 11).
  3. Younger J, Parkitny L, McLain D. The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. Clinical Rheumatology. 2014;33(4):451–459. doi:10.1007/s10067-014-2517-2
  4. Toljan K, Vrooman B. Low-Dose Naltrexone (LDN) — Review of Therapeutic Utilization. Medical Sciences (Basel). 2018;6(4):82. doi:10.3390/medsci6040082
Active Ingredients

Naltrexone

Directions

Consult your prescriber.

Instructions

Use the medication as prescribed by your doctor. The information provided is not intended to cover all possible uses. This information is generalized and not intended as specific medical advice. If you have questions about the use of your prescription, please contact your prescriber.

Shipping

Troches and suppositories require refrigeration (ice packs) and will incur an extra charge of $19.95 per order.

Reviews

Customer Reviews

6 reviews

Susan

5/5Review rating

Thanks for the great customer service

LJ

5/5Review rating

I started using LDN for my dog's colon cancer. They didn't get clear margins when they debulked the tumor and she was given 3 months - that was 3 years ago! Anyway, I started it for pain due to RA, lupus, dermatositis, interstitial cystitis... I had been on opiates - mostly because I couldn't take NSAIDs as I was on blood thinners due to the lupus coagulopathy - so I stopped the opiates, allowed a short washout period (they can't be taken together) - and started the LDN with immediate improvement. My life has improved so much - not only are my chronic conditions and pain better but I'm no longer dealing with the opiate-related falls, fogginess, addiction and the destruction on my body.

Paula

5/5Review rating

I'm so thankful to have found Carefirst Specialty Pharmacy, and their Low Dose Naltrexone (LDN) This medicine has been amazing in helping with my Hashimotos, sleep, pain, etc. Their customer service is excellent as well.

Theresa

5/5Review rating

Ldn has helped with so many debilitating effects of lyme disease babesia, hashimotos ,and fibromyalgia.

villagecat

5/5Review rating

OMG... I suffered for over a year with severe itching that would come on at night, I couldn't sleep, my skin began to thicken. I had fibromyalgia and anxiety. I have been diagnosed with Hashimoto's autoimmune disease, This med. starting at 1.5mg. within days the itching stopped, I worked up to 4.5mg by increasing 1mg. a month. I live where there is only 1 compound pharmacy charging me 60$ for 30 pills. Being able to get 120 pills for under$60 is a blessing considering all the other expenses I have for additional supplements. THANK YOU THANK YOU!!! These people were great to work with.

Theresa

5/5Review rating

From every angle or department.. CFS staff and customer service are the best. So wonderful and understand what your asking or saying. Also are very patient . Well trained , well spoken with common sense, politeness, and incredible attitudes. It is great to hear the cheer and understanding in their voices alone ,especially when you are ill, or just not having a good day! Oh the medication !!...is a miracle pill for me. Has helped with symptoms of Lyme disease tremendously !! Would suggest the FDA come out of its hole on this one!

Leave a Review

We are a nationally accredited PCAB compounding pharmacy and a .Pharmacy verified website. A verified .Pharmacy website designation ensures our patients and prescribing partners that our website is verified and safe.

https://safe.pharmacy/buy-safely/?url=cfspharmacy.pharmacy

Actual product image may vary.

Naltrexone is typically used to treat opioid use disorder and alcohol abuse disorder. It is classified as an opioid antagonist blocking the effects of exogenously administered opioids. However, at low doses (0.5mg–6mg), oral naltrexone has been prescribed for its possible analgesia and anti-inflammatory effects, which have not been observed at higher doses. Low dose naltrexone may be beneficial for the treatment of various conditions including chronic pain and autoimmune illnesses.

Pronunciation

nal trek sown

Brand Names

Vivitrol, ReVia, APO-Naltrexone

Drug Class

Antidote, Opioid Antagonist

🔬 Mechanism of Action

As a pure opioid antagonist, naltrexone competes with opioid receptors and can displace opioid drugs from the receptors. Naltrexone antagonizes the effects of opioids with long-lasting effects. At low doses, this transient receptor blockade is believed to trigger an upregulation of endogenous opioid production, resulting in anti-inflammatory and analgesic effects.

📊 Administration & Dosing

  • May be taken by mouth with or without food. Taking with food may minimize gastrointestinal side effects.
  • LDN doses typically range from 0.5mg to 6mg daily — contact your healthcare provider for specific dosing instructions.
  • To minimize risk of withdrawal, patients should be opioid-free for at least 7–10 days before starting.

⚠️ Drug Interactions

  • Opioids: Do not take together — may precipitate opioid withdrawal and reduce opioid effectiveness.
  • Bremelanotide: Do not take together — may result in naltrexone treatment failure.
  • Opioid antagonists (Naldemedine, Naloxegol): May increase risk of opioid withdrawal.

🚨 Adverse Effects

Common side effects:

• Nausea / vomiting

• Gastrointestinal pain / cramps

• Joint or muscle pain

• Difficulty sleeping

• Anxiety

• Headaches

Tell your doctor immediately if you experience: yellowing of the skin (jaundice), suicidal thoughts, symptoms of opioid withdrawal, or mild symptoms that do not go away.

🤰 Pregnancy, Breastfeeding & Pediatrics

  • Pregnancy: Testing is recommended prior to initiation. Naltrexone and its metabolite (6-beta-naltrexol) cross the placenta. Limited data exists — speak to your doctor about risks and benefits.
  • Breastfeeding: Naltrexone and 6-beta-naltrexol are present in breast milk. Discuss risk and benefits with your doctor.
  • Pediatrics: Safety and effectiveness have not been established in pediatric patients.

📚 References

  1. Naltrexone [monograph]. In: Lexicomp Online [online database]. Hudson, OH: Lexicomp (accessed 2020 June 11).
  2. Naltrexone [monograph]. In: Micromedex [online database]. Greenwood Village, CO: Truven Health Analytics (accessed 2020 June 11).
  3. Younger J, Parkitny L, McLain D. The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. Clinical Rheumatology. 2014;33(4):451–459. doi:10.1007/s10067-014-2517-2
  4. Toljan K, Vrooman B. Low-Dose Naltrexone (LDN) — Review of Therapeutic Utilization. Medical Sciences (Basel). 2018;6(4):82. doi:10.3390/medsci6040082

Naltrexone

Consult your prescriber.

Use the medication as prescribed by your doctor. The information provided is not intended to cover all possible uses. This information is generalized and not intended as specific medical advice. If you have questions about the use of your prescription, please contact your prescriber.

Troches and suppositories require refrigeration (ice packs) and will incur an extra charge of $19.95 per order.

Customer Reviews

6 reviews

Susan

5/5Review rating

Thanks for the great customer service

LJ

5/5Review rating

I started using LDN for my dog's colon cancer. They didn't get clear margins when they debulked the tumor and she was given 3 months - that was 3 years ago! Anyway, I started it for pain due to RA, lupus, dermatositis, interstitial cystitis... I had been on opiates - mostly because I couldn't take NSAIDs as I was on blood thinners due to the lupus coagulopathy - so I stopped the opiates, allowed a short washout period (they can't be taken together) - and started the LDN with immediate improvement. My life has improved so much - not only are my chronic conditions and pain better but I'm no longer dealing with the opiate-related falls, fogginess, addiction and the destruction on my body.

Paula

5/5Review rating

I'm so thankful to have found Carefirst Specialty Pharmacy, and their Low Dose Naltrexone (LDN) This medicine has been amazing in helping with my Hashimotos, sleep, pain, etc. Their customer service is excellent as well.

Theresa

5/5Review rating

Ldn has helped with so many debilitating effects of lyme disease babesia, hashimotos ,and fibromyalgia.

villagecat

5/5Review rating

OMG... I suffered for over a year with severe itching that would come on at night, I couldn't sleep, my skin began to thicken. I had fibromyalgia and anxiety. I have been diagnosed with Hashimoto's autoimmune disease, This med. starting at 1.5mg. within days the itching stopped, I worked up to 4.5mg by increasing 1mg. a month. I live where there is only 1 compound pharmacy charging me 60$ for 30 pills. Being able to get 120 pills for under$60 is a blessing considering all the other expenses I have for additional supplements. THANK YOU THANK YOU!!! These people were great to work with.

Theresa

5/5Review rating

From every angle or department.. CFS staff and customer service are the best. So wonderful and understand what your asking or saying. Also are very patient . Well trained , well spoken with common sense, politeness, and incredible attitudes. It is great to hear the cheer and understanding in their voices alone ,especially when you are ill, or just not having a good day! Oh the medication !!...is a miracle pill for me. Has helped with symptoms of Lyme disease tremendously !! Would suggest the FDA come out of its hole on this one!

Leave a Review