Human Medicine

Low Dose Naltrexone (LDN)

LDN refers to daily dosages approximately 10% of the typical opioid addiction treatment dose. At these low levels, naltrexone exhibits paradoxical properties — including analgesia and anti-inflammatory actions — shown to benefit patients with immune system dysfunction.

Immediate releaseDosing flexibilityFewer ingredients

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LDN Research Trust 2026 MemberTrusted Compounding Pharmacy

Low Dose Naltrexone that puts patients first.

Low Dose Naltrexone (LDN) refers to daily dosages of naltrexone that are approximately 10% or less of the typical opioid addiction treatment dosage, commonly up to 5mg. These dosages are compounded at compounding pharmacies and require a prescription. At the low dosage level, naltrexone exhibits paradoxical properties, including analgesia and anti-inflammatory actions, which have not been reported at larger dosages. Studies have shown that it can be beneficial for people with conditions marked by immune system dysfunction.

LDN represents the use of an established prescription medication in many other domains of medical treatment. Although many studies have shown promise with LDN therapy, more studies are being conducted to investigate the effectiveness of LDN in treating a range of autoimmune illnesses. LDN is frequently used in conjunction with the traditional prescription medications typical for treating these various conditions with the exception of narcotics.

Immediate releaseDosing flexibilityFewer ingredients

The LDN Pharmacy You Can Trust

Why doctors choose CareFirst Specialty Pharmacy

Nationally Accredited Compounding Pharmacy (PCAB/ACHC, .Pharmacy, PCCA and IACP Member.)
Tablets with dosing flexibility and fewer ingredients than capsules.
Immediate release tablets with no calcium, gluten, lactose, corn, dairy, soy or dyes.
Fillers that do not interfere with absorption.
State-of-the-art compounding facility with stringent quality control and independent lab testing.
Multiple strengths ready to ship from an experienced team with excellent service.
Licensed in over 50 states.

We Compound LDN

Tablets (0.5mg - 6mg)
Sublingual Tablets
Oral Sublingual Drops
Oral Suspensions (90-day beyond use date)
Veggie Capsules (Sucrose, Mannitol, Acidophilus, Loxoral, Vitamin C or other)
Topical Creams
Ultra Low Dose Naltrexone (ULDN)

This Medication Requires a Prescription

To process your order we will require a prescription from you or your prescriber. We will only compound and dispense upon receipt of a valid patient specific prescription.

Need help?

Our team can coordinate with your provider to get what you need quickly.

LDN Research Trust 2026 Member

Accredited & recognized

CareFirst Specialty Pharmacy is proud to be an LDN Research Trust 2026 member.

Low Dose Naltrexone (LDN) Side Effects

LDN is known to be safe and well-tolerated with a minimal side effect profile. Common reports include vivid dreams and interrupted sleep during the initial adjustment; these tend to develop quickly and decrease over time.

LDN is compatible with most prescription medications except for narcotics. Because it blocks the effects of narcotics and could cause withdrawal symptoms, it should only be started after those drugs are out of your system.

Caution is taken with Hashimoto's patients as LDN can rapidly decrease autoimmune antibodies and may require a decrease in thyroid replacement medication as the body works more effectively.

Conditions LDN Has Been Prescribed For

ALS (Lou Gehrig's disease)
Alzheimer's disease
Ankylosing spondylitis
Anti-aging
Autism
Celiac disease
Chronic fatigue syndrome
Crohn's disease
Endometriosis
Fibromyalgia
Thyroid Disorders (Hashimoto's and Graves' Disease)
Inflammatory bowel disease
Lupus
Multiple sclerosis (MS)
Parkinson's disease
Psoriasis
Rheumatoid arthritis
Sarcoidosis
Scleroderma
Ulcerative colitis

Low Dose Naltrexone (LDN) Cost and Availability

LDN needs to be compounded by an experienced and accredited compounding pharmacy. It must be compounded as an immediate release capsule or tablet and without the use of certain fillers and binders. Pricing can vary considerably by region and pharmacy. Check our shipping information page to see what states we're licensed in!

LDN Informational Video

Hear more about how LDN is compounded, who it can benefit, and how our team supports you through prescription and refills.

Patient focusedAccredited facilityExpert support

Available Low Dose Naltrexone Products

Explore strengths, fillers, and dosage forms tailored to your prescription.

HumanLow Dose Naltrexone

Low Dose Naltrexone

Low dose naltrexone may be beneficial for the treatment of various conditions including chronic pain and autoimmune illnesses. Naltrexone is typically used to treat opioid use disorder and alcohol abuse disorder. It is classified as an opioid antagonist blocking the effects of exogenously administered opioids. Naltrexone at low doses (0.5mg - 6mg) has been prescribed for its possible analgesia and anti-inflammatory effects, which have not been observed at higher doses.

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HumanLow Dose Naltrexone